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See pdf for list of Consortium on Addictions, Stress and Trauma (CAST) members:

CAST LIST
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A double-blind randomized controlled pilot trial of N-acetylcysteine in veterans with PTSD and substance use disorders
Principal Investigator: Sudie E. Back
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Back, S. E., McCauley, J. L., Korte, K. J., Gros, D. F., Leavitt, V., Gray, K. M., ... & Kalivas, P. W. (2016). A double-blind randomized controlled pilot trial of N-acetylcysteine in veterans with PTSD and substance use disorders. The Journal of clinical psychiatry, 77(11), e1439.
Concurrent treatment of substance use disorders and PTSD using prolonged exposure: A randomized clinical trial in military veterans
Principal Investigator: Sudie E. Back
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Back, S. E., Killeen, T., Badour, C. L., Flanagan, J. C., Allan, N. P., Santa Ana, E., ... & Brady, K. T. (2019). Concurrent treatment of substance use disorders and PTSD using prolonged exposure: a randomized clinical trial in military veterans. Addictive behaviors, 90, 369-377.
Topiramate treatment of alcohol use disorder in veterans with posttraumatic stress disorder: A randomized controlled pilot trial
Principal Investigator: ​​Steven L. Batki
​

Batki, S. L., Pennington, D. L., Lasher, B., Neylan, T. C., Metzler, T., Waldrop, A., ... & Herbst, E. (2014). Topiramate treatment of alcohol use disorder in veterans with posttraumatic stress disorder: a randomized controlled pilot trial. Alcoholism: Clinical and Experimental Research, 38(8), 2169-2177. doi: 10.1111/acer.12496
A randomised controlled trial of the Flinders Program™ of chronic condition management in Vietnam veterans with co-morbid alcohol misuse, and psychiatric and medical conditions
Principal Investigator: ​​Malcolm W. Battersby

Battersby, M. W., Beattie, J., Pols, R. G., Smith, D. P., Condon, J., & Blunden, S. (2013). A randomised controlled trial of the Flinders Program™ of chronic condition management in Vietnam veterans with co-morbid alcohol misuse, and psychiatric and medical conditions. Australian & New Zealand Journal of Psychiatry, 47(5), 451-462. doi: 10.1177/0004867412471977.
Seeking Safety treatment for male veterans with a substance use disorder and post-traumatic stress disorder symptomatology
Principal Investigator: ​​Matthew Tyler Boden

​Boden, M. T., Kimerling, R., Jacobs‐Lentz, J., Bowman, D., Weaver, C., Carney, D., ... & Trafton, J. A. (2012). Seeking Safety treatment for male veterans with a substance use disorder and post‐traumatic stress disorder symptomatology. Addiction, 107(3), 578-586. doi: 10.1111/j.1360-0443.2011.03658.x.
Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: Preliminary findings
Principal Investigator: ​​Kathleen T. Brady

​Brady, K. T., Dansky, B. S., Back, S. E., Foa, E. B., & Carroll, K. M. (2001). Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: Preliminary findings. Journal of Substance Abuse Treatment, 21(1), 47-54. doi: 10.1016/S0740-5472(01)00182-9.
​Sertraline in the treatment of co‐occurring alcohol dependence and posttraumatic stress disorder
Principal Investigator: ​​Kathleen T. Brady

​Brady, K. T., Sonne, S., Anton, R. F., Randall, C. L., Back, S. E., & Simpson, K. (2005). Sertraline in the treatment of co‐occurring alcohol dependence and posttraumatic stress disorder. Alcoholism: Clinical and Experimental Research, 29(3), 395-401. doi: 0.1097/01.ALC.0000156129.98265.57.
Web intervention for OEF/OIF veterans with problem drinking and PTSD symptoms: A randomized clinical trial
Principal Investigator: ​​Deborah J. Brief

Brief, D. J., Rubin, A., Keane, T. M., Enggasser, J. L., Roy, M., Helmuth, E., Hermos, J., Lachowicz, M., Rybin, D., & Rosenbloom, D. (2013). Web intervention for OEF/OIF veterans with problem drinking and PTSD symptoms: A randomized clinical trial. Journal of Consulting and Clinical Psychology, 81(5), 890–900. doi: 10.1037/a0033697.​
Integrated Cognitive Behavioral Therapy (ICBT) for PTSD and substance use in Iraq and Afghanistan veterans: A feasibility study*
Principal Investigator: ​​Christy Capone

Capone, C., Eaton, E., McGrath, A. C., & McGovern, M. P. (2014). Integrated cognitive behavioral therapy (ICBT) for PTSD and substance use in Iraq and Afghanistan veterans: a feasibility study. Journal of Traumatic Stress Disorders & Treatment, 3(4). doi:10.4172/2324-8947.1000134. 
Is Integrated CBT effective in reducing PTSD symptoms and substance use in Iraq and Afghanistan veterans? Results from a randomized clinical trial*
Principal Investigator: ​​Christy Capone

Capone, C., Presseau, C., Saunders, E., Eaton, E., Hamblen, J., & McGovern, M. (2018). Is integrated CBT effective in reducing PTSD symptoms and substance use in Iraq and Afghanistan veterans? Results from a randomized clinical trial. Cognitive Therapy and Research, 42(6), 735-746.​
Concurrent Naltrexone and Prolonged Exposure Therapy for patients with comorbid alcohol dependence and PTSD: A randomized clinical trial
Principal Investigator: ​​Edna B. Foa

Foa EB, Yusko DA, McLean CP, et al. Concurrent Naltrexone and Prolonged Exposure Therapy for Patients With Comorbid Alcohol Dependence and PTSD: A Randomized Clinical Trial. JAMA. 2013;310(5):488–495. doi: 10.1001/jama.2013.8268.​
Promising treatments for women with comorbid PTSD and substance use disorders
​
Principal Investigator: ​​Denise A. Hien

Hien, D. A., Cohen, L. R., Miele, G. M., Litt, L. C., & Capstick, C. (2004). Promising treatments for women with comorbid PTSD and substance use disorders. American journal of Psychiatry, 161(8), 1426-1432.
Multisite randomized trial of behavioral interventions for women with co-occurring PTSD and substance use disorders
​
Principal Investigator: ​​Denise A. Hien

Hien, D. A., Wells, E. A., Jiang, H., Suarez-Morales, L., Campbell, A. N., Cohen, L. R., ... & Hansen, C. (2009). Multisite randomized trial of behavioral interventions for women with co-occurring PTSD and substance use disorders. Journal of consulting and clinical psychology, 77(4), 607-619.
Combining seeking safety with sertraline for ​PTSD and alcohol use disorders: A randomized controlled trial
​
Principal Investigator: ​​Denise A. Hien

Hien, D. A., Levin, F. R., Ruglass, L. M., López-Castro, T., Papini, S., Hu, M. C., ... & Herron, A. (2015). Combining seeking safety with sertraline for PTSD and alcohol use disorders: A randomized controlled trial. Journal of consulting and clinical psychology, 83(2), 359-369.
Concurrent treatment with prolonged exposure for co-occurring full or subthreshold Posttraumatic Stress Disorder and substance use disorders: A randomized clinical trial
​
Principal Investigator: ​​Denise A. Hien

Ruglass, L. M., Lopez-Castro, T., Papini, S., Killeen, T., Back, S. E., & Hien, D. A. (2017). Concurrent treatment with prolonged exposure for co-occurring full or subthreshold posttraumatic stress disorder and substance use disorders: A randomized clinical trial. Psychotherapy and psychosomatics, 86(3), 150-161.
A randomized controlled trial evaluating integrated versus phased application of evidence-based psychotherapies for military veterans with comorbid PTSD and substance use disorders
Principal Investigator: Shannon M. Kehle-Forbes & David W. Oslin

Kehle-Forbes, S. M., Chen, S., Polusny, M. A., Lynch, K. G., Koffel, E., Ingram, E., ... & Oslin, D. W. (2019). A randomized controlled trial evaluating integrated versus phased application of evidence-based psychotherapies for military veterans with comorbid PTSD and substance use disorders. Drug and alcohol dependence, 205, 107647. doi: 10.1016/j.drugalcdep.2019.107647.
Effectiveness of EMDR in patients with substance use disorder and comorbid PTSD: Study protocol for a randomized controlled trial
Principal Investigator: Annett Lotzin

Schäfer, I., Chuey-Ferrer, L., Hofmann, A., Lieberman, P., Mainusch, G., & Lotzin, A. (2017). Effectiveness of EMDR in patients with substance use disorder and comorbid PTSD: study protocol for a randomized controlled trial. BMC psychiatry, 17(1), 1-7. doi: 10.1186/s12888-017-1255-9​.
Randomized controlled trial of two brief alcohol interventions for OEF/OIF veterans 
Principal Investigator: Meghan E. McDevitt-Murphy

​McDevitt-Murphy, M. E., Murphy, J. G., Williams, J. L., Monahan, C. J., Bracken-Minor, K. L., & Fields, J. A. (2014). Randomized controlled trial of two brief alcohol interventions for OEF/OIF veterans. Journal of Consulting and Clinical Psychology, 82(4), 562–568. https://doi.org/10.1037/a0036714
​A Randomized Controlled Trial Comparing Integrated Cognitive Behavioral Therapy Versus Individual Addiction Counseling for Co-occurring Substance Use and Posttraumatic Stress Disorders
Principal Investigator: Mark P. McGovern

Mark P. McGovern PhD, Chantal Lambert-Harris MA, Arthur I. Alterman PhD, Haiyi Xie PhD & Andrea Meier MS (2011) A Randomized Controlled Trial Comparing Integrated Cognitive Behavioral Therapy Versus Individual Addiction Counseling for Co-occurring Substance Use and Posttraumatic Stress Disorders, Journal of Dual Diagnosis, 7:4, 207-227, DOI: 10.1080/15504263.2011.620425.
A randomized controlled trial of treatments for co-occurring substance use disorders and post-traumatic stress disorder
Principal Investigator: Mark P. McGovern

​McGovern, M. P., Lambert‐Harris, C., Xie, H., Meier, A., McLeman, B., & Saunders, E. (2015). A randomized controlled trial of treatments for co‐occurring substance use disorders and post‐traumatic stress disorder. Addiction, 110(7), 1194-1204. doi: 10.1111/add.12943.
Integrated Exposure-Based Therapy for Co-occurring Posttraumatic Stress Disorder and Substance Dependence A Randomized Controlled Trial
Principal Investigator: Katherine L. Mills

integrated_exposure-based_therapy_for_co-occurring_posttraumatic_stress_disorder_and_substance_dependence_a_randomized_controlled_trial.pdf​Mills KL, Teesson M, Back SE, et al. Integrated Exposure-Based Therapy for Co-occurring Posttraumatic Stress Disorder and Substance Dependence: A Randomized Controlled Trial. JAMA. 2012;308(7):690–699. doi:10.1001/jama.2012.9071.​
"Seeking safety" : Outcome of a new cognitive-behavioral psychotherapy for women with posttraumatic stress disorder and substance dependence 
Principal Investigator: Lisa M. Najavits 

​Najavits, L. M., Weiss, R. D., Shaw, S. R., & Muenz, L. R. (1998). “Seeking safety”: Outcome of a new cognitive‐behavioral psychotherapy for women with posttraumatic stress disorder and substance dependence. Journal of Traumatic Stress: Official Publication of The International Society for Traumatic Stress Studies, 11(3), 437-456. doi: 10.1023/A:1024496427434.
Seeking Safety plus exposure therapy: An outcome study on dual diagnosis men
Principal Investigator: Lisa M. Najavits 

Lisa M. Najavits, Martha Schmitz, Silke Gotthardt & Roger D. Weiss (2005) Seeking Safety Plus Exposure Therapy: An Outcome Study on Dual Diagnosis Men, Journal of Psychoactive Drugs, 37:4, 425-435, doi: 10.1080/02791072.2005.10399816.
​A pilot study of seeking safety therapy with OEF/OIF veterans
Principal Investigator: Sonya B. Norman 

Norman, S. B., Wilkins, K. C., Tapert, S. F., Lang, A. J., & Najavits, L. M. (2010). A pilot study of seeking safety therapy with OEF/OIF veterans. Journal of Psychoactive Drugs, 42, 83-87. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962932/.
​Treatment engagement: Female survivors of intimate partner violence in treatment for PTSD and Alcohol Use Disorder
Principal Investigator: Sonya B. Norman 

Myers, U.S., Browne, K.C., & Norman, S.B. (2015). Treatment Engagement: Female Survivors of Intimate Partner Violence in Treatment for PTSD and Alcohol Use Disorder. Journal of Dual Diagnosis, 11, 238-247. doi: 10.1080/15504263.2015.1113762.
Efficacy of integrated exposure therapy vs integrating coping skills therapy for comorbid Postraumatic Stress Disorder and Alcohol Use Disorder: A randomized clinical trial
Principal Investigator: Sonya B. Norman 

Norman, S.B., Trim, R., Haller, M., Davis, B.C., Myers, U.S., Colvonen, P.J., Blanes, E., Lyons, R., Siegel, E.Y., Angkaw, A.C., Norman, G.J., Mayes, T. (2019). Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry, 76(8):791-799. doi:10.1001/jamapsychiatry.2019.0638.
Integrated cognitive behavioral therapy versus cognitive processing therapy for adults with depression, substance use disorder, and trauma
Principal Investigator: Sonya B. Norman 

Haller, M., Norman, S.B., Cummins, K., Trim, R.S., Xu, X., Cui, R., Allard, C.B., Brown, S.A., & Tate, S.R. (2016). Integrated cognitive behavioral therapy versus cognitive processing therapy for adults with depression, substance use disorder, and trauma. Journal of Substance Abuse Treatment, 62, 38-48. doi: 10.1016/j.jsat.2015.11.005
Treating trauma in addiction with EMDR: A pilot study
Principal Investigator: Béatrice Perez-Dandieu & Géraldine Tapia

Perez-Dandieu, B., & Tapia, G. (2014). Treating trauma in addiction with EMDR: a pilot study. Journal of Psychoactive Drugs, 46(4), 303-309. doi: 10.1080/02791072.2014.921744.
Concurrent treatment of PTSD and substance use disorders using Prolonged Exposure (COPE): A pilot study in alcohol-dependent women
Principal Investigator: Anna Persson

Persson, A., Back, S. E., Killeen, T. K., Brady, K. T., Schwandt, M. L., Heilig, M., & Magnusson, Å. (2017). Concurrent treatment of PTSD and substance use disorders using prolonged exposure (COPE): A pilot study in alcohol-dependent women. Journal of addiction medicine, 11(2), 119. doi:10.1097/ADM.0000000000000286​.
Naltrexone and Disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder
Principal Investigator: Ismene L. Petrakis

Petrakis, I. L., Poling, J., Levinson, C., Nich, C., Carroll, K., Ralevski, E., & Rounsaville, B. (2006). Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder. Biological Psychiatry, 60(7), 777-783. doi: 10.1016/j.biopsych.2006.03.074.​
Noradrenergic vs Serotonergic Antidepressant with or without Naltrexone for veterans with PTSD and comorbid alcohol dependence
Principal Investigator: Ismene L. Petrakis

Petrakis, I. L., Ralevski, E., Desai, N., Trevisan, L., Gueorguieva, R., Rounsaville, B., & Krystal, J. H. (2012). Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology, 37(4), 996-1004. doi: 10.1038/npp.2011.283.
Prazosin for Veterans with Posttraumatic Stress Disorder and comorbid alcohol dependence: A clinical trial
Principal Investigator: Ismene L. Petrakis

Petrakis, I. L., Desai, N., Gueorguieva, R., Arias, A., O'Brien, E., Jane, J. S., ... & Ralevski, E. (2016). Prazosin for veterans with posttraumatic stress disorder and comorbid alcohol dependence: A clinical trial. Alcoholism: Clinical and Experimental Research, 40(1), 178-186. doi: 10.1111/acer.12926.
Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study
Principal Investigator: Ismene L. Petrakis

Petrakis, I., Ralevski, E., Arias, A. J., DeNegre, D., Newcomb, J., Gianoli, M., ... & Yoon, G. (2020). Zonisamide as an Adjunctive Treatment to Cognitive Processing Therapy for Veterans With Posttraumatic Stress Disorder and Comorbid Alcohol Use Disorder: A Pilot Study. The American Journal on Addictions. doi: 10.1111/ajad.13061.
Virtual reality and cellular phones as a complementary intervention for veterans with PTSD and substance use disorders
Principal Investigator: M. Zachary Rosenthal

Rosenthal, M. Z. (2013). Virtual Reality and Cellular Phones as a Complementary Intervention for Veterans with PTSD and Substance Use Disorders. Duke University Medical Center Durham United States.​
Unpublished Study, Title Forthcoming
Principal Investigator: ​​Michael Saladin
Randomized controlled trial of cognitive behaviour therapy for comorbid Post-traumatic Stress Disorder and alcohol use disorders
Principal Investigator: Claudia Sannibale

Sannibale, C., Teesson, M., Creamer, M., Sitharthan, T., Bryant, R. A., Sutherland, K., ... & Peek‐O'Leary, M. (2013). Randomized controlled trial of cognitive behaviour therapy for comorbid post‐traumatic stress disorder and alcohol use disorders. Addiction, 108(8), 1397-1410. doi: 0.1111/add.12167.​
Incentivizing attendance to prolonged exposure for PTSD with opioid use disorder patients: A randomized controlled trial
Principal Investigator: Rebecca L. Schacht & Jessica M. Peirce

Schacht, R. L., Brooner, R. K., King, V. L., Kidorf, M. S., & Peirce, J. M. (2017). Incentivizing attendance to prolonged exposure for PTSD with opioid use disorder patients: A randomized controlled trial. Journal of Consulting and Clinical Psychology, 85(7), 689–701. doi: 10.1037/ccp0000208.​
A multisite randomized controlled trial of Seeking Safety vs. Relapse Prevention Training for women with co-occuring Posttraumatic Stress Disorder and substance use disorder
Principal Investigator: Ingo Schäfer

Schäfer, I., Lotzin, A., Hiller, P., Sehner, S., Driessen, M., Hillemacher, T., ... & Grundmann, J. (2019). A multisite randomized controlled trial of Seeking Safety vs. Relapse Prevention Training for women with co-occurring posttraumatic stress disorder and substance use disorders. European journal of psychotraumatology, 10(1), 1577092. doi: 10.1080/20008198.2019.1577092.​
Couple treatment for alcohol use disorder and Posttraumatic Stress Disorder: Pilot results from U.S. military veterans and their partners
Principal Investigator: Jeremiah A. Schumm & Kathleen M. Chard

Schumm, J. A., Monson, C. M., O'Farrell, T. J., Gustin, N. G., & Chard, K. M. (2015). Couple treatment for alcohol use disorder and posttraumatic stress disorder: Pilot results from US military veterans and their partners. Journal of Traumatic Stress, 28(3), 247-252. doi: 10.1002/jts.22007.​
A pilot trial of Prazosin, an Alpha-1 Adrenergic Antagonist, for comorbid alcohol dependence and Posttraumatic Stress Disorder*
Principal Investigator: Tracy L. Simpson

Simpson, T. L., Malte, C. A., Dietel, B., Tell, D., Pocock, I., Lyons, R., ... & Saxon, A. J. (2015). A pilot trial of prazosin, an alpha‐1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder. Alcoholism: Clinical and Experimental Research, 39(5), 808-817. doi: 0.1111/acer.12703.​
Cognitive Processing Therapy and relapse prevention for comorbid PTSD and Alcohol Use Disorder: A randomized clinical trial*
Principal Investigator: ​​Tracy L. Simpson

Simpson, T.L., Kaysen, D.L., Fleming, C., Rhew, I.C., Jaffe, A.E., Desai, S., Hien, D.A., Berliner, L., Donnovan, D., Resick, P. (under review) Cognitive Processing Therapy and Relapse Prevention for Comorbid PTSD and Alcohol Use Disorder: A Randomized Clinical Trial. American Journal of Psychiatry.​
Unpublished Study, Title Forthcoming
Principal Investigator: ​​Susan Sonne
A controlled examination of two coping skills for daily alcohol use and PTSD symptom severity among dually diagnosed individuals
Principal Investigator: Cynthia A. Stappenbeck

Stappenbeck, C. A., Luterek, J. A., Kaysen, D., Rosenthal, C. F., Gurrad, B., & Simpson, T. L. (2015). A controlled examination of two coping skills for daily alcohol use and PTSD symptom severity among dually diagnosed individuals. Behaviour research and therapy, 66, 8-17. doi: 10.1016/j.brat.2014.12.013.​
Trauma-focused treatment for posttraumatic stress disorder combined with CBT for severe substance use disorder: A randomized controlled trial
Principal Investigator: ​​Debora van Dam

​van Dam, D., Ehring, T., Vedel, E., & Emmelkamp, P. M. (2013). Trauma-focused treatment for posttraumatic stress disorder combined with CBT for severe substance use disorder: a randomized controlled trial. BMC psychiatry, 13(1), 172. doi: 10.1186/1471-244X-13-172.
Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence
Principal Investigator: Anka A. Vujanovic

Vujanovic, A. A., Smith, L. J., Green, C. E., Lane, S. D., & Schmitz, J. M. (2018). Development of a novel, integrated cognitive-behavioral therapy for co-occurring posttraumatic stress and substance use disorders: A pilot randomized clinical trial. Contemporary Clinical Trials, 65, 123-129. doi: 10.1016/j.cct.2017.12.013 

Vujanovic, A. A., Smith, L. J., Tipton, K. P., & Schmitz, J. M. (2019). A novel, integrated cognitive-behavioral therapy for co-occurring posttraumatic stress and substance use disorders: A case study. Cognitive and Behavioral Practice, 26, 307-322.  doi: 10.1016/j.cbpra.2018.03.003 
A cognitive-behavioral treatment for incarcerated women with substance abuse disorder and Posttraumatic Stress Disorder: findings from a pilot study
Principal Investigator: Caron Zlotnick

Zlotnick, C., Najavits, L. M., Rohsenow, D. J., & Johnson, D. M. (2003). A cognitive-behavioral treatment for incarcerated women with substance abuse disorder and posttraumatic stress disorder: Findings from a pilot study. Journal of Substance Abuse Treatment, 25(2), 99-105. doi: 10.1016/S0740-5472(03)00106-5.​
Randomized controlled pilot study of Cognitive-Behavioral Therapy in a sample of incarcerated women with substance use disorder and PTSD
Principal Investigator: Caron Zlotnick

Zlotnick, C., Johnson, J., & Najavits, L. M. (2009). Randomized controlled pilot study of cognitive-behavioral therapy in a sample of incarcerated women with substance use disorder and PTSD. Behavior Therapy, 40(4), 325-336. doi: 10.1016/j.beth.2008.09.004. ​
*We only collected aggregate data from these studies
NIAAA-funded R01​ (MPIs: Hien & Morgan-Lopez): 1 R01 AA025853
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