A novel way to harmonize a large body of research into a

usable tool for clinicians and researchers to better treat

comorbid Posttraumatic Stress Disorder (PTSD) and Alcohol/Other

​Drug Use Disorders (AODs)

The project uses innovative methodology to integrate and analyze data from over thirty National Institute on Alcohol Abuse and Alcoholism (NIAAA)– and National Institute on Drug Abuse (NIDA)– funded post-traumatic stress disorder (PTSD) and alcohol/other drug use disorder (AOD) treatment trials. If the project is successful, it will be the first such study to provide definitive recommendations to practitioners and policymakers regarding (1) the comparative effectiveness of different types of PTSD/AOD treatments, (2) which types of treatments work best for which types of patients, and (3) whether the key mechanisms of action operates differently across treatment types​

Aim 1

Aim 2 

Develop scale scores of PTSD and AOD severity in the presence of study-level measurement non-invariance

Aim 3

Test individual-, treatment-, and study-level moderators to identify for whom each of the treatment models work best 

Compare the effectiveness of evidence-based treatment models for comorbid PTSD and AOD 
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Aim 4

Test for potential mediators of treatment effects on AODs across treatment models 
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"We seek harm to none and harmony for all.”
- Amanda Gorman