A novel way to harmonize a large body of research into a

usable tool for clinicians and researchers to better treat

comorbid Posttraumatic Stress Disorder (PTSD) and Alcohol/Other

​Drug Use Disorders (AODs)

This data science project uses innovative methodology to integrate and analyze data from thirty nine post-traumatic stress disorder (PTSD) and alcohol/other drug use disorder (AOD) treatment trials, many funded by National Institute on Alcohol Abuse and Alcoholism (NIAA)- and National Institute on Drug Abuse (NIDA). Systematic reviews, network meta-analyses and individual patient data meta-analyses now provide definitive recommendations to practitioners and policymakers regarding (1) the comparative effectiveness of different types of PTSD/AOD treatments, (2) which types of treatments work best for which types of patients, and (3) whether the key mechanisms of action operates differently across treatment types.

Project Harmony 1.0:

Aim 1

Aim 2 

Develop scale scores of PTSD and AOD severity in the presence of study-level measurement non-invariance

Compare the effectiveness of evidence-based treatment models for comorbid PTSD and AOD 
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Aim 3

Test for potential mediators of treatment effects on AODs across treatment models 
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Aim 4

Test individual-, treatment-, and study-level moderators to identify for whom each of the treatment models work best 

Project Harmony 2.0:

Aim 1

Conduct new analyses on recovery-focused outcomes to evaluate comparative effects of behavioral, pharmacological, and combination treatments for PTSD/SUD

Aim 2

Expand MIPD/IDA methodologies to individual-level statistical inferences regarding the proportion of patients with clinically significant improvement/deterioration across treatment classes.

Aim 3

Update and extend MIPD comparative effectiveness analysis of PTSD severity, SUD/AUD consumption, and recovery outcomes to an expanded 60-trial, 8000+ participant PH dataset.

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"We seek harm to none and harmony for all.”
- Amanda Gorman